The New England journal of medicine
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Randomized Controlled Trial Comparative Study
Catheter Ablation in End-Stage Heart Failure with Atrial Fibrillation.
The role of catheter ablation in patients with symptomatic atrial fibrillation and end-stage heart failure is unknown. ⋯ Among patients with atrial fibrillation and end-stage heart failure, the combination of catheter ablation and guideline-directed medical therapy was associated with a lower likelihood of a composite of death from any cause, implantation of a left ventricular assist device, or urgent heart transplantation than medical therapy alone. (Funded by Else Kröner-Fresenius-Stiftung; CASTLE-HTx ClinicalTrials.gov number, NCT04649801.).