The New England journal of medicine
-
Randomized Controlled Trial Multicenter Study
Trial of Vancomycin and Cefazolin as Surgical Prophylaxis in Arthroplasty.
The addition of vancomycin to beta-lactam prophylaxis in arthroplasty may reduce surgical-site infections; however, the efficacy and safety are unclear. ⋯ The addition of vancomycin to cefazolin prophylaxis was not superior to placebo for the prevention of surgical-site infections in arthroplasty among patients without known MRSA colonization. (Funded by the Australian National Health and Medical Research Council; Australian New Zealand Clinical Trials Registry number, ACTRN12618000642280.).