The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study
Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression.
Electroconvulsive therapy (ECT) and subanesthetic intravenous ketamine are both currently used for treatment-resistant major depression, but the comparative effectiveness of the two treatments remains uncertain. ⋯ Ketamine was noninferior to ECT as therapy for treatment-resistant major depression without psychosis. (Funded by the Patient-Centered Outcomes Research Institute; ELEKT-D ClinicalTrials.gov number, NCT03113968.).