The New England journal of medicine
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Randomized Controlled Trial Multicenter Study
Tenecteplase for Ischemic Stroke at 4.5 to 24 Hours without Thrombectomy.
Tenecteplase is an effective thrombolytic agent for eligible patients with stroke who are treated within 4.5 hours after the onset of stroke. However, data regarding the effectiveness of tenecteplase beyond 4.5 hours are limited. ⋯ In this trial involving Chinese patients with ischemic stroke due to large-vessel occlusion, most of whom did not undergo endovascular thrombectomy, treatment with tenecteplase administered 4.5 to 24 hours after stroke onset resulted in less disability and similar survival as compared with standard medical treatment, and the incidence of symptomatic intracranial hemorrhage appeared to be higher. (Funded by the National Natural Science Foundation of China and others; TRACE-III ClinicalTrials.gov number, NCT05141305.).
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Randomized Controlled Trial Multicenter Study
Oral Nirmatrelvir-Ritonavir as Postexposure Prophylaxis for Covid-19.
Clinical trials of treatments for coronavirus disease 2019 (Covid-19) have not shown a significant benefit of postexposure prophylaxis. ⋯ In this placebo-controlled trial, postexposure prophylaxis with nirmatrelvir-ritonavir for 5 or 10 days did not significantly reduce the risk of symptomatic SARS-CoV-2 infection. (Funded by Pfizer; ClinicalTrials.gov number, NCT05047601.).
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Review Case Reports
Necrotizing Soft-Tissue and Retropharyngeal Space Infections and Mediastinitis.