The New England journal of medicine
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Randomized Controlled Trial
Azithromycin to Reduce Mortality - An Adaptive Cluster-Randomized Trial.
Twice-yearly mass distribution of azithromycin to children is a promising intervention to reduce childhood mortality in sub-Saharan Africa. The World Health Organization recommended restricting distribution to infants 1 to 11 months of age to mitigate antimicrobial resistance, although this more limited treatment had not yet been tested. ⋯ Azithromycin distributions to children 1 to 59 months of age significantly reduced mortality and was more effective than treatment of infants 1 to 11 months of age. Antimicrobial resistance must be monitored. (Funded by the Bill and Melinda Gates Foundation; AVENIR ClinicalTrials.gov number, NCT04224987.).
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Comment Letter Case Reports
Andexanet for Factor Xa Inhibitor-Associated Acute Intracerebral Hemorrhage. Reply.