The New England journal of medicine
The most recent articles from:
N. Engl. J. Med.
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Comment Letter
Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia.
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Randomized Controlled Trial Comparative Study
Cefepime-Taniborbactam in Complicated Urinary Tract Infection.
Carbapenem-resistant Enterobacterales species and multidrug-resistant Pseudomonas aeruginosa are global health threats. Cefepime-taniborbactam is an investigational β-lactam and β-lactamase inhibitor combination with activity against Enterobacterales species and P. aeruginosa expressing serine and metallo-β-lactamases. ⋯ Cefepime-taniborbactam was superior to meropenem for the treatment of complicated UTI that included acute pyelonephritis, with a safety profile similar to that of meropenem. (Funded by Venatorx Pharmaceuticals and others; CERTAIN-1 ClinicalTrials.gov number, NCT03840148.).