International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Apr 2006
Randomized Controlled TrialRadiotherapy in pediatric medulloblastoma: quality assessment of Pediatric Oncology Group Trial 9031.
To evaluate the potential influence of radiotherapy quality on survival in high-risk pediatric medulloblastoma patients. ⋯ Despite major treatment deviations in more than half of fully evaluable patients, underdosage or treatment volume misses were not associated with a worse event-free or overall survival.
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Int. J. Radiat. Oncol. Biol. Phys. · Apr 2006
Comparative StudyA modified inflammatory bowel disease questionnaire and the Vaizey Incontinence questionnaire are more sensitive measures of acute gastrointestinal toxicity during pelvic radiotherapy than RTOG grading.
Simple scales with greater sensitivity than Radiation Therapy Oncology Group (RTOG) grading to detect acute gastrointestinal toxicity during pelvic radiotherapy, could be clinically useful. ⋯ The IBDQ and Vaizey questionnaires are reliable and sensitive, offering greater insight into the severity and range of symptoms compared with RTOG grading.
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Int. J. Radiat. Oncol. Biol. Phys. · Apr 2006
An estimation of radiobiologic parameters from clinical outcomes for radiation treatment planning of brain tumor.
To estimate a plausible set of radiobiologic parameters such as alpha, alpha/beta values, from clinical outcomes for biologically based radiation treatment planning of brain tumors. ⋯ A plausible set of radiobiologic parameters for gliomas was estimated based on clinical data. These parameters can reasonably predict most of the clinical results. They may be used to design new treatment fractionation schemes and to evaluate and optimize treatment plans.
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Int. J. Radiat. Oncol. Biol. Phys. · Apr 2006
Randomized Controlled TrialPrognostic index score and clinical prediction model of local regional recurrence after mastectomy in breast cancer patients.
To develop clinical prediction models for local regional recurrence (LRR) of breast carcinoma after mastectomy that will be superior to the conventional measures of tumor size and nodal status. ⋯ The prognostic score and predictive index are useful methods to estimate the risk of LRR in breast cancer patients after mastectomy and for estimating the potential benefits of PMRT. These models provide additional information criteria for selection of patients for PMRT, compared with the traditional selection criteria of nodal status and tumor size.
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Int. J. Radiat. Oncol. Biol. Phys. · Apr 2006
Comparative StudyAnatomy-based inverse optimization in high-dose-rate brachytherapy combined with hypofractionated external beam radiotherapy for localized prostate cancer: comparison of incidence of acute genitourinary toxicity between anatomy-based inverse optimization and geometric optimization.
To evaluate the advantages of anatomy-based inverse optimization (IO) in planning high-dose-rate (HDR) brachytherapy. ⋯ The results of this study suggest that anatomy-based IO is superior to GO for dose optimization in HDR brachytherapy for prostate cancer.