International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Jul 2008
Clinical TrialDosimetric effect of translational and rotational errors for patients undergoing image-guided stereotactic body radiotherapy for spinal metastases.
To investigate the dosimetric effects of translational and rotational patient positioning errors on the treatment of spinal and paraspinal metastases using computed tomography image-guided stereotactic body radiotherapy. The results of this study provide guidance for the treatment planning process and recognition of the dosimetric consequences of daily patient treatment setup errors. ⋯ For the best dosimetric results, spinal stereotactic treatments should have setup translational errors of < or =1 mm and rotational errors of < or =2 degrees .
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Int. J. Radiat. Oncol. Biol. Phys. · Jul 2008
Multicenter StudyRadiotherapy to improve local control regardless of surgical margin and malignancy grade in extremity and trunk wall soft tissue sarcoma: a Scandinavian sarcoma group study.
Adjuvant radiotherapy has during the past decades become increasingly used in the treatment of localized soft tissue sarcoma. We evaluated the effect of radiotherapy (RT) on local recurrence rates (LRRs) in Scandinavia between 1986 and 2005. ⋯ The results of our study have shown that adjuvant RT effectively prevents local recurrence in soft tissue sarcoma, irrespective of the tumor depth, malignancy grade, and surgical margin status. The effect was most pronounced in deep-seated, high-grade tumors, even when removed with a wide surgical margin.
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Int. J. Radiat. Oncol. Biol. Phys. · Jul 2008
Is response to radiotherapy in patients related to the severity of pretreatment pain?
The primary objective of this study was to determine whether there is a relationship between the severity of pretreatment pain and response to palliative radiotherapy (RT) for painful bone metastases. ⋯ There was no significant difference in terms of the proportion of responders (patients with complete or partial response) and nonresponders in terms of painful bone metastases among patients presenting with mild, moderate, or severe pain. Patients with moderate pain should be referred for palliative RT.
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Int. J. Radiat. Oncol. Biol. Phys. · Jul 2008
Comparative StudyProton radiotherapy for childhood ependymoma: initial clinical outcomes and dose comparisons.
To report preliminary clinical outcomes for pediatric patients treated with proton beam radiation for intracranial ependymoma and compare the dose distributions of intensity-modulated radiation therapy with photons (IMRT), three-dimensional conformal proton radiation, and intensity-modulated proton radiation therapy (IMPT) for representative patients. ⋯ Preliminary disease control with proton therapy compares favorably with the literature. Dosimetric comparisons show the advantage of proton radiation compared with IMRT in the treatment of ependymoma. Further sparing of normal structures appears possible with IMPT. Superior dose distributions were accomplished with fewer beam angles with the use of protons and IMPT.