International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Jul 2008
Clinical TrialIntensity-modulated radiotherapy for resected mesothelioma: the Duke experience.
To assess the safety and efficacy of intensity-modulated radiotherapy (IMRT) after extrapleural pneumonectomy for malignant pleural mesothelioma. ⋯ With limited follow-up, 45-Gy IMRT provides reasonable local control for mesothelioma after extrapleural pneumonectomy. However, treatment-related pulmonary toxicity remains a significant concern. Care should be taken to minimize the dose to the remaining lung to achieve an acceptable therapeutic ratio.
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Int. J. Radiat. Oncol. Biol. Phys. · Jul 2008
Validation of supervised automated algorithm for fast quantitative evaluation of organ motion on magnetic resonance imaging.
To validate a correlation coefficient template-matching algorithm applied to the supervised automated quantification of abdominal-pelvic organ motion captured on time-resolved magnetic resonance imaging. ⋯ Supervised automated quantification of organ motion captured on magnetic resonance imaging using a correlation coefficient template-matching algorithm was efficient, accurate, and may play an important role in off-line adaptive approaches to intrafraction motion management.
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Int. J. Radiat. Oncol. Biol. Phys. · Jul 2008
Three-dimensional motion of liver tumors using cine-magnetic resonance imaging.
To measure the three-dimensional motion of liver tumors using cine-magnetic resonance imaging (MRI) and compare it to the liver motion assessed using fluoroscopy. ⋯ The results of our study have shown that cine-MRI can be used to directly assess liver tumor motion in three dimensions. Tumor motion did not correlate well with the diaphragm motion measured using kilovoltage fluoroscopy. The tumor motion data from cine-MRI can be used to facilitate individualized planning target volume margins to account for breathing motion.
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Int. J. Radiat. Oncol. Biol. Phys. · Jul 2008
Clinical TrialDose escalation for prostate cancer using the three-dimensional conformal dynamic arc technique: analysis of 542 consecutive patients.
To present the results of dose escalation using three-dimensional conformal dynamic arc radiotherapy (3D-ART) for prostate cancer. ⋯ Three-dimensional-ART is a feasible modality allowing for dose escalation (no increase in toxicity has been observed with higher doses). However, the dose increase from 76 to 80 Gy was not associated with better tumor outcome. Further investigation is warranted for better understanding of the dose effect for prostate cancer.