International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Nov 2009
Study of robustness of IMPT and IMRT for prostate cancer against organ movement.
Intensity-modulated radiotherapy with photons (IMRT) and protons (IMPT) produces dose distributions that have high conformality to the planning target volume and sufficient sparing of the organs at risk if calculated on a single static computed tomography (CT) scan. For prostate cancer patients, organ movement with related changes to the density distribution in the irradiated volume occurs during the treatment course. We evaluated the sensitivity of IMPT and IMRT plans to organ movement. ⋯ The sensitivities of IMPT and IMRT to organ movement are of the same order if appropriate planning strategies are applied. The latter is especially crucial for IMPT.