International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Sep 2009
Multicenter StudyDetermining the incidence of pain flare following palliative radiotherapy for symptomatic bone metastases: results from three canadian cancer centers.
To determine the incidence of pain flare following radiotherapy (RT) for painful bone metastases. ⋯ More than one third of the enrolled patients experienced a pain flare. Identifying at-risk individuals and managing potential pain flares is crucial to achieve an optimal level of care.
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Int. J. Radiat. Oncol. Biol. Phys. · Sep 2009
Successful treatment of high risk and recurrent pediatric desmoids using radiation as a component of multimodality therapy.
To evaluate the role of radiation therapy (RT) as a component of multimodality therapy for pediatric desmoids. ⋯ Local control is difficult to achieve in pediatric patients with desmoids. In the setting in which negative surgical margins cannot be achieved, RT plays a key role in achieving NED status. Even after multiple recurrences, successful salvage is achievable, particularly when high-dose focal therapy is incorporated.
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Int. J. Radiat. Oncol. Biol. Phys. · Sep 2009
Multicenter StudyMaximum vs. mono androgen blockade and the risk of recurrence in men with localized prostate cancer undergoing brachytherapy.
We examined whether maximum androgen blockade (MAB) is associated with a decreased recurrence risk vs. single-agent androgen suppression (monotherapy) for men undergoing brachytherapy (BT) for localized prostate cancer. ⋯ There are varied practice patterns in physicians' choice of the extent of concurrent ADT when used with brachytherapy for men with intermediate- or high-risk prostate cancer. Given a lack of demonstrated superiority from either ADT choice, both appear to be reasonable options.
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Int. J. Radiat. Oncol. Biol. Phys. · Sep 2009
Comparative StudyAccelerated partial breast irradiation: what is dosimetric effect of advanced technology approaches?
The present treatment planning study compared whole breast radiotherapy (WBRT) to accelerated partial breast irradiation (APBI) for different external beam techniques and geometries (e.g., free breathing [FB] and deep inspiration breath hold [DIBH]). ⋯ Although planning target volume coverage was acceptable with all techniques, the plans using the DIBH geometry resulted in a marked reduction in the normal tissue dose compared with WBRT planned in the absence of cardiac blocking. Additional study is needed to determine whether these techniques result in clinical benefits.