International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2012
Subclassification of recursive partitioning analysis Class II patients with brain metastases treated radiosurgically.
Although the recursive partitioning analysis (RPA) class is generally used for predicting survival periods of patients with brain metastases (METs), the majority of such patients are Class II and clinical factors vary quite widely within this category. This prompted us to divide RPA Class II patients into three subclasses. ⋯ Our new grading system should be considered when designing future clinical trials involving brain MET patients.
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2012
Comparative StudyCritical appraisal of Acuros XB and Anisotropic Analytic Algorithm dose calculation in advanced non-small-cell lung cancer treatments.
To assess the clinical impact of the Acuros XB algorithm (implemented in the Varian Eclipse treatment-planning system) in non-small-cell lung cancer (NSCLC) cases. ⋯ The availability of Acuros XB could improve patient dose estimation, increasing the data consistency of clinical trials.
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2012
Interfractional positional variability of fiducial markers and primary tumors in locally advanced non-small-cell lung cancer during audiovisual biofeedback radiotherapy.
To evaluate implanted markers as a surrogate for tumor-based setup during image-guided lung cancer radiotherapy with audiovisual biofeedback. ⋯ Although marker-based image guidance may decrease the risk for geometric miss compared with bony anatomy-based positioning, the observed displacements between markers and tumor centroids indicate the need for repeated soft tissue imaging, particularly in situations with large tumor volume change and large initial marker-to-tumor centroid distance.
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2012
Positron emission tomography for assessing local failure after stereotactic body radiotherapy for non-small-cell lung cancer.
We analyzed whether positron emission tomography (PET)/computed tomography standardized uptake values (SUVs) after stereotactic body radiotherapy (SBRT) could predict local recurrence (LR) in non-small-cell lung cancer (NSCLC). ⋯ PET was helpful for distinguishing SBRT-induced consolidation from LR. SUVs obtained more than 6 months after SBRT for NSCLC were associated with local failure. A maximum SUV greater than 5, especially at more than 6 months after SBRT, should prompt biopsy to rule out LR.
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2012
Single-fraction radiosurgery for presumed intracranial meningiomas: efficacy and complications from a 22-year experience.
To define the rate of tumor control and factors associated with radiation-related complications after single-fraction radiosurgery (SRS) for patients with imaging defined intracranial meningiomas. ⋯ Single-fraction SRS at the used dose range provides a high rate of tumor control for patients with imaging defined intracranial meningiomas. However, treatment failures were noted after 10 years emphasizing the need for long-term imaging follow-up after meningioma SRS.