International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Jan 2006
STI571 (Gleevec) improves tumor growth delay and survival in irradiated mouse models of glioblastoma.
Glioblastoma multiforme (GBM) is a devastating brain neoplasm that is essentially incurable. Although radiation therapy prolongs survival, GBMs progress within areas of irradiation. Recent studies in invertebrates have shown that STI571 (Gleevec; Novartis, East Hanover, NJ) enhances the cytotoxicity of ionizing radiation. In the present study, the effectiveness of STI571 in combination with radiation was studied in mouse models of GBM. ⋯ These findings suggest that STI571 has the potential to augment radiotherapy and thereby improve median survival.
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Int. J. Radiat. Oncol. Biol. Phys. · Jan 2006
Comparative StudyIs intensity-modulated radiotherapy better than conventional radiation treatment and three-dimensional conformal radiotherapy for mediastinal masses in patients with Hodgkin's disease, and is there a role for beam orientation optimization and dose constraints assigned to virtual volumes?
To evaluate the role of beam orientation optimization and the role of virtual volumes (VVs) aimed at protecting adjacent organs at risk (OARs), and to compare various intensity-modulated radiotherapy (IMRT) setups with conventional treatment with anterior and posterior fields and three-dimensional conformal radiotherapy (3D-CRT). ⋯ The 5FEQ IMRT plan with dose constraints assigned to the PTV and VV allows better dose conformation than conventional treatment and 3D-CRT, notably with better protection of the heart and coronary arteries. Of concern is the "spreading out" of low doses to the rest of the patient's body.
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Int. J. Radiat. Oncol. Biol. Phys. · Jan 2006
Is IMRT needed to spare the rectum when pelvic lymph nodes are part of the initial treatment volume for prostate cancer?
To assess whether a 4-field box technique (4FBT), along with its technical refinements, is an adequate approach in terms of rectal sparing and target coverage for patients with localized prostate cancer undergoing whole-pelvic radiotherapy followed by a prostate boost and whether or not intensity-modulated radiotherapy (IMRT) is needed. ⋯ In the dose range of 70-76 Gy to the prostate, IMRT and standard techniques are equally effective in meeting rectal dose-volume constraints. However, whole-pelvis IMRT might be preferable to standard techniques for its slightly superior PTV coverage.
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Int. J. Radiat. Oncol. Biol. Phys. · Jan 2006
First report of a permanent breast 103Pd seed implant as adjuvant radiation treatment for early-stage breast cancer.
A new technique of adjuvant partial breast irradiation using 103Pd permanent breast seed implants (PBSI) is presented. The procedure is performed in a single 1-hour session under local anesthesia. ⋯ Permanent breast seed implantation seems feasible and well tolerated on these preliminary clinical data and represents an ultimate step in the reduction of treatment fraction for partial breast irradiation.
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Int. J. Radiat. Oncol. Biol. Phys. · Jan 2006
Comparative StudyConventional, conformal, and intensity-modulated radiation therapy treatment planning of external beam radiotherapy for cervical cancer: The impact of tumor regression.
Investigating the impact of tumor regression on the dose within cervical tumors and surrounding organs, comparing conventional, conformal, and intensity-modulated radiotherapy (IMRT) and the need for repeated treatment planning during irradiation. ⋯ Intensity-modulated radiation therapy is superior in sparing of critical organs compared with conventional and conformal treatment, with adequate coverage of the target volumes. Intensity-modulated radiation therapy remains superior after 30 Gy external beam radiation therapy, despite tumor regression and internal organ motion. Repeated IMRT planning can improve the sparing of the bowel and rectum in patients with substantial tumor regression.