International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · May 2005
Where to locate the isocenter? The treatment strategy for repeat trigeminal neuralgia radiosurgery.
The purpose of this study is to investigate how the spatial relationship between the isocenters of the first and second radiosurgeries affects the overall outcome. ⋯ Image registration between MR scans of the first and second radiosurgeries helps target delineation and radiosurgery treatment planning. Increasing the isocenter distance between the two radiosurgeries treated a longer segment of the trigeminal neuralgia nerve and was associated with a trend toward improved pain relief.
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Int. J. Radiat. Oncol. Biol. Phys. · May 2005
An automatic CT-guided adaptive radiation therapy technique by online modification of multileaf collimator leaf positions for prostate cancer.
To propose and evaluate online adaptive radiation therapy (ART) using in-room computed tomography (CT) imaging that detects changes in the target position and shape of the prostate and seminal vesicles (SVs) and then automatically modifies the multileaf collimator (MLC) leaf pairs in a slice-by-slice fashion. ⋯ ART corrected for interfraction changes in the position and shape of the prostate and SVs and gave dose distributions that were considerably closer to the planned dose distributions than could be achieved with simple alignment strategies that neglect shape change. The ART proposed in this investigation requires neither contouring of the daily CT images nor extensive calculations; therefore, it may prove to be an effective and clinically practical solution to the problem of interfraction shape changes.
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Int. J. Radiat. Oncol. Biol. Phys. · May 2005
Patient subsets with T1-T2, node-negative breast cancer at high locoregional recurrence risk after mastectomy.
To identify patient subsets with T1-T2N0 breast cancer at high risk of locoregional recurrence (LRR) who may warrant consideration for postmastectomy radiotherapy. ⋯ Women with pT1-T2N0 breast cancer experienced a LRR risk of approximately 20% in the presence of Grade 3 disease with LVI or Grade 3 disease, T2 tumors, and no systemic therapy. These subsets of node-negative patients warrant consideration of for postmastectomy radiotherapy.
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Int. J. Radiat. Oncol. Biol. Phys. · May 2005
Comment LetterRadiobiological parameters suitable for modeling individual outcomes cannot be obtained by analyzing heterogeneous population data with homogeneous tumor control model: in regard to D'Souza et al. (Int J Radiat Oncol Biol Phys 2004;58:1540-1548).