Clinical and experimental dermatology
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Clin. Exp. Dermatol. · Apr 2012
Spinal bombesin-recognized neurones mediate more nonhistaminergic than histaminergic sensation of itch in mice.
There may be distinct pathways for transmission of histaminergic and nonhistaminergic itch, but all scratching behaviours elicited by histamine-dependent and histamine-independent pruritogens are diminished when spinal bombesin-recognized neurones are ablated. ⋯ These results suggest that spinal bombesin-recognized neurones are critical to both the histamine-dependent and histamine-independent pathways for itch, and that they mediate more nonhistaminergic than histaminergic sensation of itch in mice.
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Clin. Exp. Dermatol. · Apr 2012
Letter Case ReportsUse of tumescent anaesthesia in dermatological surgery.
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Clin. Exp. Dermatol. · Mar 2012
Refractory aphthous ulceration treated with thalidomide: a report of 10 years' clinical experience.
Thalidomide has reported efficacy in treating refractory idiopathic aphthous ulceration and aphthous ulceration in Behçet disease (BD). However, because of its potential teratogenicity and neurotoxicity, thalidomide must be used and monitored carefully. ⋯ In our experience, thalidomide works well for severe refractory aphthous ulceration, with a typical patient response reported within 4 weeks, but its use is limited by neurotoxicity. The aphthous ulceration occurring in the context of BD was more difficult to control than idiopathic aphthous ulceration.