Clinical and experimental dermatology
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Clin. Exp. Dermatol. · May 2003
ReviewThe clinical spectrum of nonbullous congenital ichthyosiform erythroderma and lamellar ichthyosis.
Until about 20 years ago, the term lamellar ichthyosis (LI) represented all nonbullous autosomal recessive ichthyoses except for harlequin ichthyosis and ichthyosis syndromes. Since the 1980s, nonbullous autosomal recessive ichthyoses have been divided into two major clinical entities, nonbullous congenital ichthyosiform erythroderma (NBCIE) and LI. The nature of scaling and intensity of erythroderma are important clinical features that distinguish between NBCIE and LI. ⋯ Mutations in any of the three known causative genes, TGM1, ALOXE3 or ALOX12B, can lead either to NBCIE or LI. Candidate genes specific to either NBCIE or LI alone have not been identified. Based on these facts, it might be better to consider NBCIE and LI as variations of a single keratinization disorder, although the classification of these autosomal recessive congenital ichthyosis patients into NBCIE or LI depending on their clinical features is still useful for practical patient management.
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Since ancient times, larval therapy has been reputed to help wound healing. Its use has recently been rediscovered and it is now enjoying increasing interest in clinical practice, as well as in research. We have investigated the effects of larval therapy on wounds in an open study of 74 patients with necrotic or sloughy chronic ulcers of different aetiologies. ⋯ No serious side-effects were observed. One-quarter of the study group experienced less pain during treatment, while 41% felt no difference in pain, and, although 34% noted an increase in pain, most of these patients wanted to continue the treatment because of subjective and objective visual improvement in wound debridement. In conclusion, we found larval therapy to be effective for debriding ulcers, easy to use and well accepted by the patients.
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Clin. Exp. Dermatol. · Sep 2002
Case ReportsTattoo ink darkening of a yellow tattoo after Q-switched laser treatment.
The popularity of tattoos is burgeoning with 20-30 million tattooed individuals in the Western World. Requests for removal can be expected to rise concurrently with increased applications. Laser removal of tattoos is potentially a more cosmetically acceptable method of removing tattoos than surgical excision or dermabrasion. ⋯ We review darkening of tattoos after laser treatment to raise awareness of this important complication. This paper will help to facilitate discussions with the patient and in obtaining informed consent prior to commencing treatment. Tattoo ink darkening of a yellow tattoo adds to the growing list of complications resulting from attempts at tattoo removal.
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Clin. Exp. Dermatol. · Jul 2001
Case ReportsCutaneous larva migrans contracted in England: a reminder.
We report a case of cutaneous larva migrans contracted in England. This case serves as a reminder that the lack of travel abroad should not preclude the diagnosis. We discuss clinical presentation and management of cutaneous larva migrans.