Archives of pathology & laboratory medicine
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Arch. Pathol. Lab. Med. · Apr 2002
Comparative StudyCoronary angiographic findings in patients with clinical unstable angina according to cardiac troponin I and T concentrations in serum.
Elevated cardiac troponin levels have been reported to identify unstable angina patients at high risk. ⋯ Patients with unstable angina who have significant release of cTnI and/or cTnT have evidence of more complex lesions on coronary angiography, supporting the hypothesis that both troponins might be used without distinction as surrogate markers for microembolization from thrombus formation on a disrupted plaque.
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Arch. Pathol. Lab. Med. · Apr 2001
Alveolar hemorrhage and renal microangiopathy in systemic lupus erythematosus.
Acute alveolar hemorrhage in systemic lupus erythematosus usually occurs as a pulmonary-renal syndrome. In most cases, the lungs show "bland" alveolar hemorrhage with little or no inflammation. Whether this alveolar injury is similar to the better-defined noninflammatory renal lupus vasculopathy is unresolved. ⋯ Our findings indicate that alveolar hemorrhage in systemic lupus erythematosus, characterized by bland alveolar wall changes, is pathogenetically similar to the lupus microangiopathy of the kidney. In both lung and kidney, the pathogenesis of the microvascular injury appears to be related to immune complex deposition and the induction of apoptosis.
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Arch. Pathol. Lab. Med. · Dec 2000
Review Case ReportsAcute fulminant hepatic failure in a woman treated with phenytoin and trimethoprim-sulfamethoxazole.
Massive hepatic necrosis following exposure to phenytoin and trimethoprim-sulfamethoxazole is a rare occurrence and to the best of our knowledge has not been reported previously. Acute hepatic failure following administration of trimethoprim-sulfamethoxazole has rarely been seen, and only 4 cases have been well documented pathologically. ⋯ Autopsy findings revealed acute fulminant hepatic failure. This case demonstrates the effects of chemical-chemical interactions in the potentiation of hepatotoxicity of single agents and specifically illustrates the need for discontinuing trimethoprim-sulfamethoxazole in the presence of early liver injury.