Spine
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Clinical Trial
The use of magnetic resonance imaging to evaluate lumbar muscle activity during trunk extension exercise at varying intensities.
Descriptive, repeated measures analysis of exercise-induced changes in lumbar muscle transverse relaxation time (T2). ⋯ Muscle functional MRI can be used to characterize lumbar muscle function during trunk extension exercise. The levels and recruitment patterns of the lumbar extensors, as measured by muscle T2 shifts, vary with exercise intensity. Future research is needed to assess the mechanism of the nonlinear relationship between T2 shifts and exercise intensity, and to clarify the effects of fatigue and the order of exercise presentation on the T2 response of the lumbar extensors.
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Correlation between previously validated questionnaires. ⋯ As opposed to what has been shown in other cultural settings, FAB have virtually no clinical relevance in Spanish LBP patients who are treated in the National Health Service and who are in a potentially active working situation. The influence of FAB on disability is minimal and much less than that of pain severity, and their contribution to the patient's quality of life is irrelevant. Further studies should explore the potential value of FAB in other Latin-Mediterranean countries.
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Prospective consecutive series. ⋯ To our knowledge, this study has been the first attempt to analyze anatomic changes in lateral spondylolisthesis using CT. It may offer further insight into the pathogenesis of adult lumbar scoliosis.
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An external compression model was used to evaluate gene and protein expression in intervertebral discs with moderate disc degeneration. ⋯ Experimental moderate disc degeneration is characterized by a loss of BMP-2/4 and COL2 positive cells, although gene expression of disc constituents, catabolic enzymes, and growth factors is stimulated to reestablish disc integrity.
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A posterolateral lumbar fusion model in rats. ⋯ Alendronate inhibits spine fusion in rats. Fusion masses in alendronate-treated animals appeared radiographically larger and denser than those in control animals despite lower fusion rates. Quantitative histomorphometry confirmed that alendronate inhibited bone graft resorption and incorporation. We recommend that patients undergoing spine arthrodesis should not take alendronate until fusion is achieved.