Spine
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Comparative Study
Is obesity overrated as a "risk factor" for poor outcomes in chronic occupational spinal disorders?
Prospective cohort study. ⋯ Obesity is more prevalent and severe in chronic occupational spinal disorders when entering a functional restoration program as the final step in a prolonged treatment regimen. We conclude that obesity, even gross obesity, has no significant impact on outcomes of an interdisciplinary functional restoration program for patients disabled an average of 16 months.
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Comparative 3-dimensional biomechanical testing. ⋯ The iliosacral fixation with 2 6.5 mm AO-cancellous screws for complete sacroiliac dislocation demonstrated the highest stiffness and the short spinal instrumentation the poorest stiffness. All other fixation techniques could be generally considered of equivalent stability value.
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Comparative Study
Prevalence, risk factors, and preference-based health states of low back pain in a Turkish population.
A community-based cross-sectional survey was conducted using face-to-face interviews. ⋯ In comparison with other developing countries, the prevalence of LBP is higher in Turkey and approximates prevalence estimates of LBP in developed countries. LBP is associated with occupation. Smoking is not associated with having LBP. This study also shows that LBP influences disability and quality of life.
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Comparative Study
Injection of nuclear factor-kappa B decoy into the sciatic nerve suppresses mechanical allodynia and thermal hyperalgesia in a rat inflammatory pain model.
In vitro and in vivo study of a rat inflammatory pain model using nuclear factor-kappa B decoy. ⋯ Nuclear factor-kappa B decoy was conveyed and transduced into dorsal root ganglion both in vivo and in vitro. Additionally, nuclear factor-kappa B decoy reduced mechanical allodynia and thermal hyperalgesia in the rat inflammatory pain model, suggesting that inhibition of nuclear factor-kappa B with nuclear factor-kappa B decoy may represent a key mechanism for mediating inflammation or reducing inflammatory pain.