Spine
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Randomized Controlled Trial Comparative Study
Circumferential fusion improves outcome in comparison with instrumented posterolateral fusion: long-term results of a randomized clinical trial.
Prospective randomized clinical study with a 5- to 9-year follow-up period. ⋯ Circumferential lumbar fusion demands more extensive operative resources compared with posterolateral lumbar fusion. However, 5 to 9 years after surgery, the circumferentially fused patients had a significantly improved outcome compared with those treated by means of posterolateral fusion. These new results not only emphasize the superiority of circumferential fusion in the complex pathology of the lumbar spine but are also strongly supported in all of the validated questionnaires used in the study.
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Comparative Study
Mathematical calculation of pedicle subtraction osteotomy size to allow precision correction of fixed sagittal deformity.
This is a retrospective review of 15 consecutive fixed sagittal plane deformity patients who have undergone pedicle subtraction osteotomies. The focus of this article is the application of a trigonometric equation that calculates the degree of correction needed to achieve sagittal balance. The intraoperative predictive accuracy and clinical radiographic results of using this mathematical equation are discussed. ⋯ By using a simple mathematical equation, one can reliably determine the degree of pedicle subtraction osteotomy needed for correction of sagittal deformity. This technique is reproducible and has led to successful clinical outcomes.
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Comparative Study
Prevalence, risk factors, and preference-based health states of low back pain in a Turkish population.
A community-based cross-sectional survey was conducted using face-to-face interviews. ⋯ In comparison with other developing countries, the prevalence of LBP is higher in Turkey and approximates prevalence estimates of LBP in developed countries. LBP is associated with occupation. Smoking is not associated with having LBP. This study also shows that LBP influences disability and quality of life.
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Comparative Study
Injection of nuclear factor-kappa B decoy into the sciatic nerve suppresses mechanical allodynia and thermal hyperalgesia in a rat inflammatory pain model.
In vitro and in vivo study of a rat inflammatory pain model using nuclear factor-kappa B decoy. ⋯ Nuclear factor-kappa B decoy was conveyed and transduced into dorsal root ganglion both in vivo and in vitro. Additionally, nuclear factor-kappa B decoy reduced mechanical allodynia and thermal hyperalgesia in the rat inflammatory pain model, suggesting that inhibition of nuclear factor-kappa B with nuclear factor-kappa B decoy may represent a key mechanism for mediating inflammation or reducing inflammatory pain.