Spine
-
Prospective consecutive series. ⋯ Posterior indirect reduction, transpedicular hydroxyapatite grafting, and pedicle screw fixation could provide reliable neurologic improvement in patients with incomplete neurologic deficit, and could prevent the development of kyphosis. This technique does not require fusion to a segment, thereby preserves thoracolumbar motion.
-
Comparative Study
Insulin-like growth factor-1 treatment prevents anti-Fas antibody-induced apoptosis in endplate chondrocytes.
In vitro investigation of vertebral endplate chondrocyte apoptosis. ⋯ Fas antibody induces apoptosis and decreases Integrin-alpha1 and FAK expression in cultured endplate chondrocytes; IGF-1 is protective against these changes.