Spine
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Retrospective review. ⋯ Posterior correction and fixation is effective for treating pseudarthrosis with kyphosis in ankylosing spondylitis. No anterior fusion procedure was necessary.
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Using a retrograde tracing method and immunohistochemistry, we assessed the expression of activating transcription factor 3 (ATF3), a marker of nerve injury, and growth-associated protein 43 (GAP-43), a marker of axonal growth, in dorsal root ganglion (DRG) neurons innervating the lumbar intervertebral discs in rats. ⋯ ATF3-IR and GAP-43-IR neurons were significantly increased in the NP group. These results suggested that exposure of the nucleus pulposus to the outside of the anulus fibrosus induced nerve injury and in growth into the discs. These findings may explain discogenic lower back pain in patients with lumbar disc degeneration.
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Prospective cohort study. ⋯ Except for male gender, the primary determinants for improvement in pain, functional limitations, and quality of life were not associated with RTW. Although there is a large coherence in the improvement in the outcome measures, RTW seems primarily determined by the level of experienced functional limitations.