Spine
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Comparative Study
Activated macrophage-like THP-1 cells modulate anulus fibrosus cell production of inflammatory mediators in response to cytokines.
Anulus fibrosus (AF) cells obtained from patients undergoing surgery were cocultured with macrophage-like cells and production of inflammatory mediators was analyzed by quantitative assay. ⋯ We conclude that exposure to macrophages, as can be expected after anular injury, can result in enhanced response to local inflammation. Although changes were observed in all inflammatory mediators after macrophage exposure, the most significant change was observed in IL-6 and IL-8, implicating these mediators in development of symptomatic disc.
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Randomized Controlled Trial Comparative Study
Urgent surgical decompression compared to methylprednisolone for the treatment of acute spinal cord injury: a randomized prospective study in beagle dogs.
Experimental dog model of acute spinal cord injury. ⋯ In the setting of acute and persistent spinal cord compression in beagle dogs, surgical decompression 6 hours after injury, with or without methylprednisolone, is more effective for improving neurologic recovery than methylprednisolone alone.
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Cross-cultural adaptation and cross-sectional psychometric testing in a convenience sample of patients with low back pain. ⋯ The results of this study indicate that the Chinese version of the ODI 2.1 is a reliable and valid instrument for the measurement of functional status in patients with low back pain.
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Case Reports Comparative Study
Indications for cervical pedicle screw instrumentation in nontraumatic lesions.
Retrospective clinical study. ⋯ There is an indication of cervical PS fixation for destructive lesions because of a high fusion rate with improvement of nape pain. On the other hand, there is no indication in cases of typical CSM and OPLL if a potential risk of vertebral artery or nerve injury is taken into account.
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Case Reports
Lumbar epidural capillary hemangioma presenting as lumbar disc herniation disease: case report.
A case of lumbar spinal epidural hemangioma is presented. ⋯ We have reported for the first lumbar epidural capillary hemangioma patient in literature. These lesions are benign and surgical treatment is curative.