Spine
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Comparative Study
Activated macrophage-like THP-1 cells modulate anulus fibrosus cell production of inflammatory mediators in response to cytokines.
Anulus fibrosus (AF) cells obtained from patients undergoing surgery were cocultured with macrophage-like cells and production of inflammatory mediators was analyzed by quantitative assay. ⋯ We conclude that exposure to macrophages, as can be expected after anular injury, can result in enhanced response to local inflammation. Although changes were observed in all inflammatory mediators after macrophage exposure, the most significant change was observed in IL-6 and IL-8, implicating these mediators in development of symptomatic disc.
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Comparative Study
Patient activation and adherence to physical therapy in persons undergoing spine surgery.
Prospective longitudinal study. ⋯ Increased patient activation is associated with improved adherence with physical therapy as reflected in attendance and engagement.
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Comparative Study
Blood conservation techniques in spinal deformity surgery: a retrospective review of patients refusing blood transfusion.
A retrospective review. ⋯ These blood conservation techniques allow satisfactory completion of deformity surgery on those patients not willing to be transfused and without major anesthetic or medical complications.
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Cross-cultural adaptation and cross-sectional psychometric testing in a convenience sample of patients with low back pain. ⋯ The results of this study indicate that the Chinese version of the ODI 2.1 is a reliable and valid instrument for the measurement of functional status in patients with low back pain.
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Comparative Study
Dynamic angular three-dimensional measurement of multisegmental thoracolumbar motion in vivo.
Method validation and in vivo motion segment study. ⋯ This method offered accurate multisegmental dynamic-recording facilities. The dynamic exercises showed high reproducibility. The ranges of motion for extension/flexion and lateral bending differed from those reported in previous studies. The coupling patterns were only partly consistent because of large interindividual variation. The measurement error was comparable with that of other invasive methods.