Spine
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Comparative Study
Neuroprotective effects of caspase-3 inhibition on functional recovery and tissue sparing after acute spinal cord injury.
We used gene microarrays and found that caspase-related death genes were upregulated. We tested caspase inhibition and evaluated its effect on the spinal cord after traumatic injury. ⋯ These results indicate neuroprotection at both the cellular level and with substantial functional recovery, suggesting caspase-3 inhibition may be a viable therapy in the early hours after experimental SCI.