Spine
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Comparative Study
Tumor necrosis factor-alpha in the nucleus pulposus mediates radicular pain, but not increase of inflammatory peptide, associated with nerve damage in mice.
Changes in behavior and the immunohistochemistry of dorsal root ganglion (DRG) neurons were examined using a mouse model of radicular pain. ⋯ In this study TNF-alpha contained in the NP was important for the production of radicular pain accompanied by long-lasting degeneration of DRG neurons. However, other cytokines in the NP and nerve compression may also play important roles in pain transmission. In this model system, TNF-alpha in the NP appears to mediate pain, but not cause an increase in CGRP in the DRG neurons.
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Randomized Controlled Trial Comparative Study
Effect of ramosetron on patient-controlled analgesia related nausea and vomiting after spine surgery in highly susceptible patients: comparison with ondansetron.
A prospective, randomized, double-blind clinical trial. ⋯ Ramosetron was superior to ondansetron in terms of preventing vomiting and reducing the severity of nausea related to fentanyl-based IV PCA, with less adverse events, in patients with high susceptibility, undergoing lumbar spine surgery.
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Multicenter Study Comparative Study
Cross-cultural adaptation and validation of the Norwegian version of the Tampa scale for kinesiophobia.
Translation, cross-cultural adaptation, and validation of a self-report questionnaire. ⋯ The Norwegian version of the TSK was easily comprehended and demonstrated satisfactory validity and reliability for the assessment of fear of movement and/or (re)injury in patients with sciatica due to disc herniation. However, responsiveness was low to moderate.
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Comparative Study
Chronic widespread pain in patients with occupational spinal disorders: prevalence, psychiatric comorbidity, and association with outcomes.
A prospective study assessing chronic widespread pain (CWP) and psychiatric comorbidities in patients with chronic disabling occupational spinal disorders (CDOSDs). ⋯ A surprisingly high frequency of CDOSD patients participating in interdisciplinary rehabilitation met criteria for CWP, though the diagnosis was generally unknown to the patient. In this large workers' compensation cohort, CWP was not associated with longer periods of disability, more prerehabilitation surgery or higher pain self-report. With appropriate rehabilitation, CWP patients can have equally successful work return and health utilization outcomes compared to non-CWP patients, despite having significantly higher rates of certain psychiatric disorders.
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Comparative Study
Annual frequency and magnitude of neck motion in healthy individuals.
Descriptive, cross-sectional design of healthy young adults. Continuous motion monitoring of the cervical spine performed outside of a laboratory setting. ⋯ Flexion-extension was the primary neck motion during normal daily living, with the majority ofmotions about all axes being less than 15 degrees . ASTM standard F2423-05 may need to be reviewed regarding flexion-extension.