Spine
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Comparative Study
Gene expression changes in dorsal root ganglion of rat experimental lumber disc herniation models.
Comprehensive overviews of gene expression changes in dorsal root ganglion (DRG) were obtained using microarrays in 2 rat models of experimental lumbar disc herniation (LDH). ⋯ Mechanical and chemical factors caused altered gene expression in the DRG at 7 days after surgery, suggesting that the mechanisms of nerve injury induced by these factors differ. The upregulation of IGF-1 might be a key factor in painful radiculopathy induced by mechanical factors.