Spine
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Prospective clinical study. ⋯ In this study, we evaluated the utility of RSA in evaluating segmental motion after ACDF and demonstrated a significant difference between segments that demonstrated radiographic evidence of fusion when compared with segments that demonstrated evidence of pseudarthrosis. RSA appears to be a quantitative technique capable of assisting in the evaluation of fusion.
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The authors investigated gait abnormalities and mechanical hypersensitivity associated with invertebral disc herniation in a rat model of radiculopathy. Further evaluation involved assessing how nucleus pulposus (NP) injury affected systemic cytokine expression and molecular changes at the dorsal root ganglion (DRG). ⋯ This model of radiculopathy provides evidence of altered gait in a model of noncompressive disc herniation. Systemic inflammation was absent, but mechanical allodynia, local inflammation, and autoreactive immune activation were observed. Future work will involve therapeutic interventions to rescue animals from the phenotype of inflammatory radiculopathy.
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A retrospective investigation of clinical and radiologic outcomes after surgical treatment for 2-level cervical spondylotic myelopathy (CSM). ⋯ Surgical managements of 2-level CSM using ACDF or ACCF were found to be similar in terms of clinical outcomes. However, 2-level ACDF was found to be superior to 1-level ACCF in terms of operation times, bleeding amounts, and radiologic results.