Spine
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Systematic review. ⋯ An attempt should be made to maintain or restore cervical lordosis in surgical intervention for cervical disorders. Strength of Statement: Weak.
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Comparative Study
Homing of mesenchymal stem cells in induced degenerative intervertebral discs in a whole organ culture system.
Homing of human bone marrow-derived mesenchymal stem cells (BMSCs) was studied using ex vivo cultured bovine caudal intervertebral discs (IVDs). ⋯ We have demonstrated for the first time that degenerative conditions induce the release of factors promoting BMSC recruitment in an ex vivo organ culture. Moreover, IGF-1 transduction of BMSCs strongly increases the rate of proteoglycan synthesis within degenerative discs. This finding offers a new delivery system for BMSCs and treatment strategy for IVD regeneration.