Spine
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A genetic association study of the tissue inhibitor of metalloproteinase-2 (TIMP-2) gene with adolescent idiopathic scoliosis (AIS) in a Chinese population. ⋯ The single-nucleotide polymorphism SNP-418G/C (rs8179090) in the promoter region of the TIMP-2 gene was not associated with the occurrence of AIS. However, it may predict curve severity of thoracic AIS. Hence, the TIMP-2 gene is a disease-modifier gene of thoracic AIS.
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Prospective clinical study developed at a tertiary teaching facility to test an adapted Brazilian Portuguese version of the Scoliosis Research Society-30 (SRS-30) questionnaire. ⋯ The adapted Brazilian version of the SRS-30 questionnaire can be used to assess the outcome of treatment for Brazilian Portuguese-speaking patients with idiopathic scoliosis.
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Clinical Trial
Effects of epidural steroid injections on blood glucose levels in patients with diabetes mellitus.
A prospective cohort study. ⋯ ESIs were noted to cause a significant increase in the blood glucose levels in diabetics. There was no correlation between preinjection diabetic control, represented by hA(1c) levels, and postinjection response. Diabetics who are candidates for ESI should be counseled that a blood glucose increase may be apparent post intervention, but effects should not last longer than approximately 2 days.
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An anatomic study of sacral inclination, pelvic incidence, pelvic lordosis, and disc degeneration in cadaveric lumbar spines. ⋯ The findings of this study show a relationship between the sacropelvic geometry and the degree of L5-S1 disc degeneration as well as L4-L5 facet degeneration in spondylolytic specimens. This relationship may prove useful in predicting the course of disc degeneration in patients with spondylolysis.