Spine
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Randomized, controlled study in a laboratory setting. Blinded observations/assessment of study outcomes. ⋯ In this commonly used rabbit posterolateral fusion model, MASTERGRAFT PUTTY in an autograft extender mode produces clinically and radiographically similar results to autograft fusion alone.
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Retrospective case series. ⋯ Posterior vertebral column resection is an effective technique providing a successful correction of stiff complex congenital deformities. However, it is a technically demanding procedure, with possible risks for major complications.
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Retrospective clinical data analysis. ⋯ Percutaneous insertion of cannulated pedicle screws in the thoracic and lumbar spine is an acceptable technique with a low complication rate in experienced hands. The overall rate of perforation is below the higher rates reported in the literature for the open technique. Complication rates including pedicle fracture were low.
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Histological, immunohistochemical, and real-time reverse transcription-polymerase chain reaction analyses of the expression of cell signaling and transcriptional factors in human ossification of ligamentum flavum (OLF). ⋯ Our results indicated that cyclic tensile strain applied to OLF cells activated their ossification through a process mediated by the β-catenin signaling pathway.
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Meta Analysis Comparative Study
A meta-analysis of comparative outcomes following cervical arthroplasty or anterior cervical fusion: results from 4 prospective multicenter randomized clinical trials and up to 1226 patients.
Meta-analysis of 4 prospective randomized controlled Food and Drug Administration (FDA) Investigational Device Exemption (IDE) clinical trials. ⋯ These findings suggest that cervical arthroplasty is superior to ACDF in overall success, neurological success, and survivorship outcomes at 24 months postoperatively.