Spine
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Retrospective cohort study of health care costs associated with the treatment of chronic low back pain (CLBP) in the United Kingdom. ⋯ Our findings confirm the substantial economic burden of CLBP, even with direct costs only.
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The immunohistochemical profile of nuclear factor-κ B (NF-κB)/p50, NF-κB/p65, matrix metalloproteinase (MMP)-9, MMP-2, and urokinase-type plasminogen activator (u-PA) proteins was examined in spinal cord tissues coming from rabbits, which underwent chronic cervical spinal cord compression. ⋯ There is a strong correlation between the immunoexpression of NF-κB/p50, NF-κB/p65, MMP-2, MMP-9, u-PA, and CSM.
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Randomized Controlled Trial Multicenter Study
Patterns of care after magnetic resonance imaging of the spine in primary care.
Retrospective cohort study. ⋯ Patients receiving MRI scans of the spine in the primary care setting are frequently referred for surgical assessment and most do not receive subsequent surgery. MRI scan results do not discriminate very well between those who will and will not undergo surgery, suggesting that alternative models for the assessment of patients with spinal complaints in primary care should be explored, particularly in jurisdictions with long wait times for elective spinal surgery consultation.
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Randomized Controlled Trial
Prognostic factors of prolonged disability in patients with chronic low back pain and lumbar degeneration in primary care: a cohort study.
A cohort study with 1-year follow-up. ⋯ Increased pain-related disability at 1 year was seen in patients with impaired fasting glucose tolerance, greater pain-related disability, higher BMI, and lower quality of life at baseline.