Spine
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Retrospective case series. ⋯ 3.
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Cross-sectional, questionnaire study. ⋯ Findings highlight extreme variability in practice associated with a notable lack of standard of care and provide a baseline for utility studies that may lead to more evidence-driven care.
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The possibility to prevent acute spinal cord injury (ASCI) by selective infliximab combined with methylprednisolone (MP) was assessed in experimental ASCI. ⋯ Infliximab combined with methylprednisolone may be an effective treatment for the recovery of ASCI. Further study is needed to determine if this neuroprotective effect is seen for long-term outcomes especially in human ASCI.
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Systematic review of interventions. ⋯ 2.
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A biomechanical human cadaveric study. ⋯ Destabilization of both the facet complex and disc was required to achieve anterior listhesis of 3.1 mm consistent with a grade 1 DLS under an applied shear force of 250 N. Sufficient listhesis was measured without radical specimen resection. Important anatomical structures for supporting spinal instrumentation were preserved such that this model can be used in future to characterize behavior of novel instrumentation prior to clinical trials.