Spine
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Observational Study
Scheuermann's Disease: Evaluation of Radiological Criteria and Population Prevalence.
Study Design: Observational population-based studyObjective: Determine the prevalence of radiographic Scheuermann's disease in a Dutch population and evaluate the consistency of diagnostic criteria. Summary of Background Data: Scheuermann's disease is a form of osteochondrosis characterized by increased posterior rounding of the thoracic spine with structural vertebral deformity. Different expert-opinion based radiological criteria exist, yet these have not been validated. ⋯ Adjustment of the kyphosis angle criterion from 45 to 40 or 35 degrees increased the number of cases marginally, corresponding to prevalence estimates not significantly different from the estimates using original criteria (4.2% [3.3-4.7%] and 4.4% [3.6%-5.2%]). Conclusion: Our results revealed a prevalence of 4.0% of radiographic Scheuermann's disease in Dutch individuals aged 45 years and over. Although there is no current gold standard for the radiographic definition, standardized scoring of independent features resulted in substantial inter-observer agreement, and different applications of diagnostic criteria did not significantly alter the classification.
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Retrospective and radiological analysis of spinopelvic sagittal alignment in Chinese patients with thoracic and thoracolumbar kyphosis. ⋯ 3.
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This is a quantitative study of heparanase isoforms expression in degenerative and nondegenerative intervertebral discs (IVDs). ⋯ The overexpression of HPSE1 and HPSE2 in the intervertebral degenerated discs suggests a role for these factors in mediating extracellular matrix remodeling in degenerative discs during disease development.
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Multicenter Study
Radiographical spinopelvic parameters and disability in the setting of adult spinal deformity: a prospective multicenter analysis.
Prospective multicenter study evaluating operative (OP) versus nonoperative (NONOP) treatment for adult spinal deformity (ASD). ⋯ ASD is a disabling condition. Prospective analysis of consecutively enrolled patients with ASD demonstrated that PT and PI-LL combined with SVA can predict patient disability and provide a guide for patient assessment for appropriate therapeutic decision making. Threshold values for severe disability (ODI > 40) included: PT 22° or more, SVA 47 mm or more, and PI - LL 11° or more.
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Retrospective, multicenter cohort study. ⋯ 4.