Spine
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Preclinical study. ⋯ This pilot study demonstrated that DDS can be fabricated to deliver sustained and therapeutic dosages of ETN and GDF5. In addition, ETN+GDF5-DDS may have greater anti-inflammatory and regenerative effects than ETN-DDS alone. Thus, intradiscal injection of controlled release TNF-α inhibitors and growth factors may be a promising treatment to reduce disk inflammation and back pain.
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A cross-sectional study was performed using the National Institutes of Health All of Us survey database. ⋯ 4.
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Retrospective. ⋯ Although the incidence of adverse events was high before 2Y, there was a substantial reduction in longer follow-up indicating complications after 2Y are less common. Complications beyond 2Y consisted mostly of mechanical issues.
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Observational Study
Proximal Junction Failure in Spine Surgery: Integrating Geometrical and Biomechanical Global Descriptors Improves GAP Score-Based Assessment.
Retrospective observational study. ⋯ BM reflects the quantitative biomechanical effect of external loads and can improve GAP accuracy. Sagittal alignments and mechanical integrated scores could be used to better prognosticate the risk of PJF.
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Retrospective database analysis. ⋯ The utilization of IONM for elective lumbar surgeries continues to gain popularity. Our results indicated that IONM use was not associated with a reduction in neurological deficits and will not support the routine use of IONM for all elective lumbar surgery.