Spine
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Retrospective cohort study. ⋯ Level IV.
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This study was aimed to investigate the potential roles of circTMTC1 in the underlying pathophysiological mechanisms of ossification of the ligamentum flavum (OLF). ⋯ Our findings suggested the circTMTC1-DDX3X-NLRP3 inflammasome signaling plays a pivotal role in osteogenic differentiation of human ligamentum flavum cells, which may provide novel diagnostic and therapeutic strategies for OLF.
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Randomized Controlled Trial Multicenter Study Comparative Study
Efficacy of Biphasic Calcium Phosphate Ceramic With a Needle-shaped Surface Topography Versus Autograft in Instrumented Posterolateral Spinal Fusion: A Randomized Trial.
A multicenter randomized controlled noninferiority trial with intrapatient comparisons. ⋯ This clinical trial demonstrates noninferiority and indicates superiority of MagnetOs Granules as a standalone ceramic when compared to autograft for posterolateral spinal fusion. These results challange the belief that autologous bone is the most optimal graft material.
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Comparative Study Observational Study
Comparison of Patients Operated for Lumbar Spinal Stenosis with and without Spondylolisthesis - A Secondary Analysis of the NORDSTEN Trials.
Observational cohort study (secondary analysis of two randomized trials). ⋯ II.
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Retrospective analysis of prospectively collected data. ⋯ Level II.