Intensive care medicine
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Intensive care medicine · Jan 1991
Case ReportsAmrinone for refractory cardiogenic shock following chloroquine poisoning.
Cardiac arrhythmias and circulatory collapse account for the high mortality reported after severe chloroquine poisoning. We have recently observed a 17-year-old man who ingested an 8 g chloroquine overdose. ⋯ Cardiogenic shock was refractory to epinephrine, dopamine and molar sodium lactate. Amrinone, a bipyridine analog, was then successfully used to improve haemodynamic conditions.
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Intensive care medicine · Jan 1991
Clinical TrialAdrenaline in treatment of septic shock: effects on haemodynamics and oxygen transport.
The effects of adrenaline on haemodynamics and oxygen transport were studied in 13 patients with septic shock persisting after optimal fluid loading. Adrenaline was administered by intravenous infusion at an increasing dose until no further benefit was seen. ⋯ There was a significant reduction in oxygen extraction ratio, but no change in shunt fraction. Adrenaline would appear to have beneficial haemodynamic effects in septic shock.