Intensive care medicine
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Intensive care medicine · Jul 1998
Comparative StudyBiochemical and ultra-structural reactions to parenteral nutrition with two different fat emulsions in rats.
To compare the effects on fat metabolism and Kupffer cell morphology by total parenteral nutrition (TPN) with two different fat emulsions. ⋯ Compared to treatment with pure LCTemulsions, treatment with MCT/LCT emulsions evoked weaker biochemical reactions in terms of lower activity of lipoprotein lipase in fat and heart together with higher serum and HDL triglyceride levels. Morphological signs of increased Kupffer cell activity such as the appearance of multiple lysosomes and fat vacuoles in the cytoplasm followed treatment with pure LCT emulsions. However, both TPN groups showed a marked increase in activities of liver lysosomal enzymes.
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Intensive care medicine · Jul 1998
Percutaneous dilatational tracheostomy--early results and long-term outcome of 326 critically ill patients.
To analyze perioperative and postoperative complications and long-term sequelae following percutaneous dilatational tracheostomy (PDT). ⋯ When performed by experienced physicians, percutaneous dilatational tracheostomy under fiberoptic guidance is a safe method. The risks of early complications and of clinically relevant tracheal stenoses are low. Subclinical tracheal stenoses are found in about 40% of patients following PDT.
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Intensive care medicine · Jul 1998
Case ReportsEthylene glycol poisoning treated by intravenous 4-methylpyrazole.
A 19-year-old woman was admitted 45 min after ethylene glycol (EG) ingestion. The initial serum EG concentration was 1.34 g/l (21.6 mmol/l), the anion gap 14.5, and the osmolal gap 24. ⋯ Ethanol therapy, hemodialysis, and sodium bicarbonate administration were not required. The half-life of EG during 4-MP therapy was 11 h, with a mean EG renal clearance of 26.9 ml/min, and a total of 65.3 g EG was eliminated unchanged in the urine. 4-MP therapy was also well tolerated.