Intensive care medicine
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Intensive care medicine · Jul 2001
Acute effects of ventilator settings on respiratory motor output in patients with acute lung injury.
During assisted mechanical ventilation, changes in ventilator settings may acutely affect the respiratory motor output via the mechanoreceptor reflex feedback system, thus interfering with patient management. This feedback system in mechanically ventilated patients with parenchymal lung injury remains largely unexplored. To investigate this, the early response of respiratory motor output to varying ventilator settings was determined in 13 sedated patients with acute lung injury. ⋯ We conclude that alterations in commonly used ventilator settings induce acute changes in respiratory timing, without affecting the respiratory drive. These changes, probably mediated via mechanoreceptor reflex feedback, are dependent on the type of the alteration in the ventilator settings.
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Intensive care medicine · Jul 2001
Brain energy metabolism during controlled reduction of cerebral perfusion pressure in severe head injuries.
To study cerebral biochemical markers with intracerebral microdialysis and bedside analysis in patients with severe head injuries treated with a controlled reduction of cerebral perfusion pressure (CPP). ⋯ The study shows that pharmacological decrease in CPP according to the "Lund concept" is associated with a normalisation of cerebral metabolism. The study also indicates that intracerebral microdialysis can be used for evaluation of new treatment strategies.
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Intensive care medicine · Jul 2001
Acute renal failure after successful cardiopulmonary resuscitation.
To assess the frequency and independent predictors of severe acute renal failure in patients resuscitated from out-of-hospital ventricular fibrillation cardiac arrest. ⋯ Severe progressive acute renal failure after cardiopulmonary resuscitation (CPR) is rare. Pre-existing haemodynamics seem to be more important for the occurrence of acute renal failure than actual hypoperfusion during resuscitation.
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Intensive care medicine · Jul 2001
Letter Case ReportsAcute zolpidem overdose leading to coma and respiratory failure.