Intensive care medicine
-
Intensive care medicine · Jul 2001
Randomized Controlled Trial Multicenter Study Clinical TrialA multicenter, open-label, prospective, randomized, dose-ranging pharmacokinetic study of the anti-TNF-alpha antibody afelimomab in patients with sepsis syndrome.
To investigate the pharmacokinetics and safety of afelimomab, a murine antibody fragment against human tumor necrosis factor (TNF)-alpha in patients with sepsis. ⋯ Multidose therapy with afelimomab was safe, well tolerated, and had predictable linear kinetics. A large randomized trial comparing afelimomab to placebo in patients with well defined sepsis has recently been completed.
-
Intensive care medicine · Jul 2001
Influence of prone position on gastric mucosal-arterial PCO2 gradients.
To evaluate the effects of mechanical ventilation in the prone position on gastric mucosal-arterial PCO2 gradients. ⋯ Mechanical ventilation in the prone position may be affiliated with increased tonometric gastric mucosal-arterial PCO2 gradients depending on the effect on intraabdominal pressure. Measuring intraabdominal pressure and/or gastric mucosal PCO2 via a nasogastric tube therefore may help to detect adverse effects of this ventilatory strategy.
-
Intensive care medicine · Jul 2001
Acute respiratory distress syndrome among trauma patients: trends in ICU mortality, risk factors, complications and resource utilization.
To evaluate trends in mortality and related factors among trauma patients who developed acute respiratory distress syndrome (ARDS). ⋯ Mortality among trauma patients with ARDS declined over the 8 years studied and was associated with less organ failure. This reduction was probably the result of new approaches to mechanical ventilation, renal failure replacement and vasoactive drug therapy.