Intensive care medicine
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Intensive care medicine · Jul 2005
Facial side effects during noninvasive positive pressure ventilation in children.
The study quantified the side effects of nasal masks use for noninvasive positive pressure ventilation (NPPV) in children. ⋯ The prevalence of facial side effects is clinically significant in children using NPPV. Systematic maxillofacial follow-up enables these effects to be identified. Remedial measures could include the change of the interface or reducing the daily use of NPPV.
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Intensive care medicine · Jul 2005
Inducible nitric oxide synthase inhibition improves intestinal microcirculatory oxygenation and CO2 balance during endotoxemia in pigs.
We examined whether selective inhibition of inducible nitric oxide synthase (iNOS) promotes intestinal microvascular oxygenation (microPO2) and CO2 off-load after endotoxic shock. ⋯ Partial blockade of NO production by 1400W increased serosal microvascular oxygenation and decreased the intestinal CO2 gap. This findings are consistent with the idea that 1400W corrects pathological flow distribution and regional dysoxia within the intestinal wall following endotoxic shock.
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Intensive care medicine · Jul 2005
Review Meta AnalysisImpact of selective decontamination of the digestive tract on fungal carriage and infection: systematic review of randomized controlled trials.
To determine the impact of the antifungal component of selective decontamination of the digestive tract on fungal carriage, infection and fungaemia. ⋯ Antifungals, as part of selective decontamination of the digestive tract, reduce fungal carriage and infection but not fungaemia in critically ill patients and may justify the inclusion of an antifungal component in the decontamination protocol.
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Intensive care medicine · Jul 2005
Randomized Controlled Trial Clinical TrialErythromycin dose of 70 mg accelerates gastric emptying as effectively as 200 mg in the critically ill.
To compare the effectiveness of 70-mg and 200-mg doses of intravenous erythromycin in improving gastric emptying in critically ill patients. ⋯ Treatment with 70 and 200 mg intravenous erythromycin are equally effective in accelerating gastric emptying in the critically ill.
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Intensive care medicine · Jul 2005
Ventilator settings as a risk factor for acute respiratory distress syndrome in mechanically ventilated patients.
A single-center retrospective study initial recently identified ventilator settings as a major risk factor for the development of acute respiratory distress syndrome (ARDS) in mechanically ventilated patients who do not have ARDS from the outset. We tested this hypothesis in a larger sample of patients prospectively enrolled in a multicenter study on mechanical ventilation. ⋯ The association with the potentially injurious initial ventilator settings, in particular large tidal volumes, suggests that ARDS in mechanically ventilated patients is in part a preventable complication. This hypothesis needs to be tested in a prospective study.