Intensive care medicine
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Intensive care medicine · Feb 2014
Letter Review Meta AnalysisUltrasound-guided radial artery catheterization: a meta-analysis of randomized controlled trials.
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Intensive care medicine · Feb 2014
Multicenter StudyPatients with faecal peritonitis admitted to European intensive care units: an epidemiological survey of the GenOSept cohort.
Faecal peritonitis (FP) is a common cause of sepsis and admission to the intensive care unit (ICU). The Genetics of Sepsis and Septic Shock in Europe (GenOSept) project is investigating the influence of genetic variation on the host response and outcomes in a large cohort of patients with sepsis admitted to ICUs across Europe. Here we report an epidemiological survey of the subset of patients with FP. ⋯ In this large cohort of patients admitted to European ICUs with FP the 6 month mortality was 31.6%. The most consistent predictors of mortality across all time points were increased age, development of acute renal dysfunction during the first week of admission, lower haematocrit and hypothermia on day 1 of ICU admission.
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Intensive care medicine · Feb 2014
Multicenter StudyImplementation of a multifaceted sepsis education program in an emerging country setting: clinical outcomes and cost-effectiveness in a long-term follow-up study.
To evaluate whether a multifaceted, centrally coordinated quality improvement program in a network of hospitals can increase compliance with the resuscitation bundle and improve clinical and economic outcomes in an emerging country setting. ⋯ A multifaceted approach to severe sepsis and septic shock patients in an emerging country setting led to high compliance with the resuscitation bundle. The intervention was cost-effective and associated with a reduction in mortality.
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Intensive care medicine · Feb 2014
ReviewAccumulation of hydroxyethyl starch in human and animal tissues: a systematic review.
To systematically review clinical and preclinical data on hydroxyethyl starch (HES) tissue storage. ⋯ Tissue storage of HES is widespread, rapid, cumulative, frequently long-lasting, and potentially harmful.
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Innate-like lymphocytes are a recently described subset of the immune response with known antibacterial properties. This human trial in critically ill patients provides the first evidence of the drop in MAIT cells during bacterial sepsis, which compounds the already known immune defects. The persistent depletion and potential for nosocomial infections is an interesting finding and one likely to provide fertile grounds for future studies.