Intensive care medicine
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Intensive care medicine · Mar 2014
Multicenter Study Observational StudyRecalibration of the delirium prediction model for ICU patients (PRE-DELIRIC): a multinational observational study.
Recalibration and determining discriminative power, internationally, of the existing delirium prediction model (PRE-DELIRIC) for intensive care patients. ⋯ In this multinational study, we recalibrated the PRE-DELIRIC model. Despite differences in the incidence of predictors between the centers in the different countries, the performance of the PRE-DELIRIC-model remained good. Following validation of the PRE-DELIRIC model, it may facilitate implementation of strategies to prevent delirium and aid improvements in delirium management of ICU patients.
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Intensive care medicine · Mar 2014
Meta AnalysisProne positioning reduces mortality from acute respiratory distress syndrome in the low tidal volume era: a meta-analysis.
Prone positioning for ARDS has been performed for decades without definitive evidence of clinical benefit. A recent multicenter trial demonstrated for the first time significantly reduced mortality with prone positioning. This meta-analysis was performed to integrate these findings with existing literature and test whether differences in tidal volume explain conflicting results among randomized trials. ⋯ Prone positioning is associated with significantly reduced mortality from ARDS in the low tidal volume era. Substantial heterogeneity across studies can be explained by differences in tidal volume.