Intensive care medicine
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Intensive care medicine · Nov 2017
Randomized Controlled Trial Multicenter StudyRandomized, multicenter trial of lateral Trendelenburg versus semirecumbent body position for the prevention of ventilator-associated pneumonia.
The lateral Trendelenburg position (LTP) may hinder the primary pathophysiologic mechanism of ventilator-associated pneumonia (VAP). We investigated whether placing patients in the LTP would reduce the incidence of VAP in comparison with the semirecumbent position (SRP). ⋯ NCT01138540.
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Intensive care medicine · Nov 2017
Randomized Controlled Trial Multicenter StudyEffect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomized trial.
Guidelines recommend administering antibiotics within 1 h of sepsis recognition but this recommendation remains untested by randomized trials. This trial was set up to investigate whether survival is improved by reducing the time before initiation of antimicrobial therapy by means of a multifaceted intervention in compliance with guideline recommendations. ⋯ Delay in antimicrobial therapy and source control was associated with increased mortality but the multifaceted approach was unable to change time to antimicrobial therapy in this setting and did not affect survival.