Intensive care medicine
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Intensive care medicine · Sep 2018
Letter Multicenter Study Observational StudyOut of the ICU shifting as a significant workload.
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Intensive care medicine · Sep 2018
LetterPositive outcomes, mortality rates, and publication bias in septic shock trials.
Abstract
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Intensive care medicine · Sep 2018
Meta AnalysisPlasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.
The soluble receptor for advanced glycation end-products (sRAGE) is a marker of lung epithelial injury and alveolar fluid clearance (AFC), with promising values for assessing prognosis and lung injury severity in acute respiratory distress syndrome (ARDS). Because AFC is impaired in most patients with ARDS and is associated with higher mortality, we hypothesized that baseline plasma sRAGE would predict mortality, independently of two key mediators of ventilator-induced lung injury. ⋯ Higher baseline plasma sRAGE was associated with higher 90-day mortality in patients with ARDS, independently of driving pressure and tidal volume, thus reinforcing the likely contribution of alveolar epithelial injury as an important prognostic factor in ARDS. Registration: PROSPERO (ID: CRD42018100241).
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Intensive care medicine · Sep 2018
Multicenter Study Comparative Study Observational StudyCorticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study.
To determine clinical predictors associated with corticosteroid administration and its association with ICU mortality in critically ill patients with severe influenza pneumonia. ⋯ Administration of corticosteroids in patients with severe influenza pneumonia is associated with increased ICU mortality, and these agents should not be used as co-adjuvant therapy.