Intensive care medicine
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Intensive care medicine · Oct 2019
Review Meta AnalysisPredictors of gastrointestinal bleeding in adult ICU patients: a systematic review and meta-analysis.
To systematically identify predictors of gastrointestinal (GI) bleeding in adult intensive care unit (ICU) patients. ⋯ We identified predictors of CIB and overt GI bleeding in adult ICU patients. These findings may be used to identify ICU patients at higher risk of GI bleeding who are most likely to benefit from stress ulcer prophylaxis.
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Intensive care medicine · Oct 2019
Randomized Controlled TrialEffects of levosimendan on respiratory muscle function in patients weaning from mechanical ventilation.
Respiratory muscle weakness frequently develops in critically ill patients and is associated with adverse outcome, including difficult weaning from mechanical ventilation. Today, no drug is approved to improve respiratory muscle function in these patients. Previously, we have shown that the calcium sensitizer levosimendan improves calcium sensitivity of human diaphragm muscle fibers in vitro and contractile efficiency of the diaphragm in healthy subjects. The main purpose of this study is to investigate the effects of levosimendan on diaphragm contractile efficiency in mechanically ventilated patients. ⋯ Levosimendan does not improve diaphragm contractile efficiency.
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Intensive care medicine · Oct 2019
Randomized Controlled Trial154 compared to 54 mmol per liter of sodium in intravenous maintenance fluid therapy for adult patients undergoing major thoracic surgery (TOPMAST): a single-center randomized controlled double-blind trial.
To determine the effects of the sodium content of maintenance fluid therapy on cumulative fluid balance and electrolyte disorders. ⋯ In adult surgical patients, sodium-rich maintenance solutions were associated with a more positive cumulative fluid balance and hyperchloremia; hypotonic fluids were associated with mild and asymptomatic hyponatremia.