Intensive care medicine
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Intensive care medicine · Apr 2019
Randomized Controlled Trial Multicenter StudyExtended-duration betrixaban versus shorter-duration enoxaparin for venous thromboembolism prophylaxis in critically ill medical patients: an APEX trial substudy.
To assess the efficacy and safety of betrixaban for venous thromboembolism (VTE) prophylaxis among critically ill patients. ⋯ http://www.clinicaltrials.gov . Unique identifier: NCT01583218.
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Intensive care medicine · Apr 2019
Randomized Controlled TrialNasal high-flow preoxygenation for endotracheal intubation in the critically ill patient: a randomized clinical trial.
Preoxygenation with high-flow therapy by nasal cannulae (HFNC) is now widespread in the intensive care unit (ICU). However, no large randomized study has assessed its relevance in non-severely hypoxemic patients. In a randomized controlled trial (PROTRACH study), we aimed to evaluate preoxygenation with HFNC vs. standard bag-valve mask oxygenation (SMO) in non-severely hypoxemic patients during rapid sequence intubation (RSI) in the ICU. ⋯ Compared with SMO, preoxygenation with HFNC in the ICU did not improve the lowest SpO2 during intubation in the non-severely hypoxemic patients but led to a reduction in intubation-related adverse events.