Intensive care medicine
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Intensive care medicine · Sep 2019
Observational StudyAnalysis of the medical response to November 2015 Paris terrorist attacks: resource utilization according to the cause of injury.
The majority of terrorist acts are carried out by explosion or shooting. The objective of this study was first, to describe the management implemented to treat a large number of casualties and their flow together with the injuries observed, and second, to compare these resources according to the mechanism of trauma. ⋯ Assistance Publique-Hôpitaux de Paris.
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Intensive care medicine · Sep 2019
Determinants of the effect of extracorporeal carbon dioxide removal in the SUPERNOVA trial: implications for trial design.
To describe the variability and determinants of the effect of extracorporeal CO2 removal (ECCO2R) on tidal volume (Vt), driving pressure (ΔP), and mechanical power (PowerRS) and to determine whether highly responsive patients can be identified for the purpose of predictive enrichment in ECCO2R trial design. ⋯ The lung-protective benefits of ECCO2R increase with higher alveolar dead space fraction, lower respiratory system compliance, and higher device performance. ADF and Crs, rather than severity of hypoxemia, should be the primary factors determining whether to enroll patients in clinical trials of ECCO2R.