Intensive care medicine
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Intensive care medicine · Aug 2022
Randomized Controlled TrialLow-dose methylprednisolone treatment in critically ill patients with severe community-acquired pneumonia.
Severe community-acquired pneumonia (CAP) requiring intensive care unit admission is associated with significant acute and long-term morbidity and mortality. We hypothesized that downregulation of systemic and pulmonary inflammation with prolonged low-dose methylprednisolone treatment would accelerate pneumonia resolution and improve clinical outcomes. ⋯ In patients with severe CAP, prolonged low-dose methylprednisolone treatment did not significantly reduce 60-day mortality. Treatment was not associated with increased complications.