Intensive care medicine
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Intensive care medicine · Nov 2023
Exploring disease axes as an alternative to distinct clusters for characterizing sepsis heterogeneity.
Various studies have analyzed sepsis subtypes, yet the reproducibility of such results remains unclear. This study aimed to determine the reproducibility of sepsis subtypes across multiple cohorts. ⋯ Cluster analysis of sepsis patients across various cohorts showed modest reproducibility. Sepsis heterogeneity is better characterized through continuous disease axes that coexist to varying degrees within the same individual instead of mutually exclusive subtypes.