Intensive care medicine
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Intensive care medicine · Dec 2024
Randomized Controlled Trial Multicenter StudyFludrocortisone dose-response relationship in septic shock: a randomised phase II trial.
The combination of intravenous hydrocortisone and enteral fludrocortisone may reduce mortality in patients with septic shock. The optimal dose and reliability of absorption of fludrocortisone in critically ill patients are unclear. ⋯ Enteral fludrocortisone resulted in detectable plasma fludrocortisone concentrations in the majority of critically ill patients with septic shock, although they varied widely indicating differing absorption and bioavailability. Its addition to hydrocortisone was not associated with shorter time to shock resolution.