Intensive care medicine
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Intensive care medicine · Jul 2001
Brain energy metabolism during controlled reduction of cerebral perfusion pressure in severe head injuries.
To study cerebral biochemical markers with intracerebral microdialysis and bedside analysis in patients with severe head injuries treated with a controlled reduction of cerebral perfusion pressure (CPP). ⋯ The study shows that pharmacological decrease in CPP according to the "Lund concept" is associated with a normalisation of cerebral metabolism. The study also indicates that intracerebral microdialysis can be used for evaluation of new treatment strategies.
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Intensive care medicine · Jul 2001
Acute renal failure after successful cardiopulmonary resuscitation.
To assess the frequency and independent predictors of severe acute renal failure in patients resuscitated from out-of-hospital ventricular fibrillation cardiac arrest. ⋯ Severe progressive acute renal failure after cardiopulmonary resuscitation (CPR) is rare. Pre-existing haemodynamics seem to be more important for the occurrence of acute renal failure than actual hypoperfusion during resuscitation.
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Intensive care medicine · Jul 2001
Letter Case ReportsAcute zolpidem overdose leading to coma and respiratory failure.
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Intensive care medicine · Jul 2001
Randomized Controlled Trial Multicenter Study Clinical TrialA multicenter, open-label, prospective, randomized, dose-ranging pharmacokinetic study of the anti-TNF-alpha antibody afelimomab in patients with sepsis syndrome.
To investigate the pharmacokinetics and safety of afelimomab, a murine antibody fragment against human tumor necrosis factor (TNF)-alpha in patients with sepsis. ⋯ Multidose therapy with afelimomab was safe, well tolerated, and had predictable linear kinetics. A large randomized trial comparing afelimomab to placebo in patients with well defined sepsis has recently been completed.